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#10417 Anti-Human Angiotensinogen (104AT 601.2.80) Mouse IgG MoAb

  • WB
Intended Use:
Research reagents
Package Size1:
100 ug
Package Size2:
10 ug
Note on Application Abbreviations
WB:Western Blotting

※ The product indicated as "Research reagents" in the column Intended Use cannot be used
  for diagnostic nor any medical purpose.
※ The datasheet listed on this page is sample only. Please refer to the datasheet
  enclosed in the product purchased before use.

Product Overview

Product Code 10417
Product Name Anti-Human Angiotensinogen (104AT 601.2.80) Mouse IgG MoAb
Intended Use Research reagents
Application WB
Species Human
Immunizing antigen Recombinant protein of human angiotensinogen
Source Mouse-Mouse hybridoma
Clone Name 104AT 601.2.80
Subclass IgG1
Purification Method Affinity purified with Protein A
Specificity Recognizes the C-terminus of human angiotensinogen (394-485 aa).
Package Form Lyophilized product from PBS containing 1 % BSA and 0.05 % NaN3
Storage Condition 2 - 8℃
Poisonous and Deleterious Substances Applicable
Cartagena Not Applicable
Package Size 1 100 ug
Package Size 2 10 ug
Remarks1 The commercial use of products without our permission is prohibited. Please make sure to contact us and obtain permission.

Product Description

Angiotensinogen is the precursor of angiotensin and is cleaved into angiotensin I and II in the renin-angiotensin system, and it has long been reported to play an important role in controlling blood pressure. In recent years interest related to the role of the renin-angiotensin system in arterial pressure control and the pathophysiology of hypertension has been shifting to its local role in various tissues. Among the studies urinary excretion of angiotensinogen in a rat model of angiotensin II (AII)-dependent hypertension has been reported to be a marker of the activity of the local intrarenal renin-angiotensin system. Intrarenal AII increases to an extent in AII-dependent hypertension that cannot be explained by the plasma AII equilibration alone, and two mechanisms, an increase in intracellular uptake of AII and an increase in intrarenal expression of angiotensinogen, have been proposed to explain it.

Note: This product is for research use only. It cannot be used as a diagnostic tool or drug.