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- #10417 Anti-Human Angiotensinogen (104AT 601.2.80) Mouse IgG MoAb
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#10417 Anti-Human Angiotensinogen (104AT 601.2.80) Mouse IgG MoAb
- Intended Use:
- Research reagents
- Application:
- WB
- Package Size1:
- 100 ug
- Package Size2:
- 10 ug
- Note on Application Abbreviations
- WB:Western Blotting
※ The product indicated as "Research reagents" in the column Intended Use cannot be used
for diagnostic nor any medical purpose.
※ The datasheet listed on this page is sample only. Please refer to the datasheet
enclosed in the product purchased before use.
Product Overview
Product Overview
Product Code | 10417 |
---|---|
Product Name | Anti-Human Angiotensinogen (104AT 601.2.80) Mouse IgG MoAb |
Intended Use | Research reagents |
Application | WB |
Species | Human |
Immunizing antigen | Recombinant protein of human angiotensinogen |
Source | Mouse-Mouse hybridoma |
Clone Name | 104AT 601.2.80 |
Subclass | IgG1 |
Purification Method | Affinity purified with Protein A |
Specificity | Recognizes the C-terminus of human angiotensinogen (394-485 aa). |
Package Form | Lyophilized product from PBS containing 1 % BSA and 0.05 % NaN3 |
Storage Condition | 2 - 8℃ |
Poisonous and Deleterious Substances | Applicable |
Cartagena | Not Applicable |
Package Size 1 | 100 ug |
Package Size 2 | 10 ug |
Remarks1 | The commercial use of products without our permission is prohibited. Please make sure to contact us and obtain permission. |
Product Description
Product Description
Angiotensinogen is the precursor of angiotensin and is cleaved into angiotensin I and II in the renin-angiotensin system, and it has long been reported to play an important role in controlling blood pressure. In recent years interest related to the role of the renin-angiotensin system in arterial pressure control and the pathophysiology of hypertension has been shifting to its local role in various tissues. Among the studies urinary excretion of angiotensinogen in a rat model of angiotensin II (AII)-dependent hypertension has been reported to be a marker of the activity of the local intrarenal renin-angiotensin system. Intrarenal AII increases to an extent in AII-dependent hypertension that cannot be explained by the plasma AII equilibration alone, and two mechanisms, an increase in intracellular uptake of AII and an increase in intrarenal expression of angiotensinogen, have been proposed to explain it.
References
References
Note: Retrieve by PMID number in displayed by abstract: http://www.ncbi.nlm.nih.gov