- HOME >
- For Researchers >
- Product Search >
- Search Result >
- #28101 Anti-Mouse/Rat Angiotensinogen (405) Rabbit IgG Affinity Purify
Product Search
#28101 Anti-Mouse/Rat Angiotensinogen (405) Rabbit IgG Affinity Purify
- Intended Use:
- Research reagents
- Application:
- WB, IHC
- Package Size1:
- 100 μg
- Package Size2:
- 10 μg
- Note on Application Abbreviations
- WB:Western Blotting
- IHC:Immunohistochemistry
※ The product indicated as "Research reagents" in the column Intended Use cannot be used
for diagnostic nor any medical purpose.
※ The datasheet listed on this page is sample only. Please refer to the datasheet
enclosed in the product purchased before use.
Product Overview
Product Overview
Product Code | 28101 |
---|---|
Product Name | Anti-Mouse/Rat Angiotensinogen (405) Rabbit IgG Affinity Purify |
Intended Use | Research reagents |
Application | WB, IHC |
Species | Mouse, Rat |
Immunizing antigen | Synthetic peptide of the C terminal part of Mouse Angiotensinogen(IGDTNPRVGEVLNSIL) |
Purification Method | Purified with antigen peptide |
Specificity | Reacts with mouse and rat Angiotensinogen. |
Package Form | Lyophilized product from PBS containing 1 % BSA and 0.05 % NaN3 |
Storage Condition | 2 - 8℃ |
Poisonous and Deleterious Substances | Applicable |
Cartagena | Not Applicable |
Package Size 1 | 100 μg |
Package Size 2 | 10 μg |
Remarks1 | The commercial use of products without our permission is prohibited. Please make sure to contact us and obtain permission. |
Product Description
Product Description
Angiotensinogen is the precursor of angiotensin and is cleaved into angiotensin I and II in the renin-angiotensin system, and it has long been reported to play an important role in controlling blood pressure. In recent years interest related to the role of the renin-angiotensin system in arterial pressure control and the pathophysiology of hypertension has been shifting to its local role in various tissues. Among the studies urinary excretion of angiotensinogen in a rat model of angiotensin II (AII)-dependent hypertension has been reported to be a marker of the activity of the local intrarenal renin-angiotensin system. Intrarenal AII increases to an extent in AII-dependent hypertension that cannot be explained by the plasma AII equilibration alone, and two mechanisms, an increase in intracellular uptake of AII and an increase in intrarenal expression of angiotensinogen, have been proposed to explain it.
References
References
- Renal denervation has blood pressure-independent protective effects on kidney and heart in a rat model of chronic kidney disease. Eriguchi M et al. Kidney Int. 2015 Jan;87(1):116-27.PMID: 24940798
- Podocyte injury enhances filtration of liver-derived angiotensinogen and renal angiotensin II generation. Matsusaka T et al. Kidney Int. 2014 May;85(5):1068-77.PMID: 24284520
- Activation of the renin-angiotensin system by a low-salt diet does not augment intratubular angiotensinogen and angiotensin II in rats. Shao W et al. Am J Physiol Renal Physiol. 2013 Mar 1;304(5):F505-14.PMID: 23303412
Note: Retrieve by PMID number in displayed by abstract: http://www.ncbi.nlm.nih.gov
FAQ
FAQ
-
Q.What is the molecule size?
-
A.Approximately 52kDa.