#10045 Anti-Human Amyloidβ (N3pE) (8E1) Mouse IgG MoAb

References (0)
FAQ (0)
Related Materials (0)
Related Products (0)

References (0)
FAQ (0)
Related Materials (0)
Related Products (0)

Intended Use：: Research reagents

Application：: WB, IHC

Package Size1：: 50 μg

Package Size2：: 5 μg

Note on Application Abbreviations: WB:Western Blotting; IHC:Immunohistochemistry

※ The product indicated as "Research reagents" in the column Intended Use cannot be used
　 for diagnostic nor any medical purpose.
※ The datasheet listed on this page is sample only. Please refer to the datasheet
　 enclosed in the product purchased before use.

Product Overview

Product Code	10045
Product Name	Anti-Human Amyloidβ (N3pE) (8E1) Mouse IgG MoAb
Maker Name	Immuno-Biological Laboratories Co., Ltd.
Intended Use	Research reagents
Application	WB, IHC
Species	Human
Immunizing antigen	Synthetic peptide for N-terminal of Human Amyloidβ modified glutamate at the 3rd N-terminal residue to pyroglutamate (Aβ(N3pE))
Source	Mouse-Mouse hybridoma (Supernatant) (X63-Ag8.653×BALB/c mouse spleen cells)
Clone Name	8E1
Subclass	IgG2a
Purification Method	Affinity Purified with antigen peptide
Specificity	Specifically detects Human Amyloidβ (N3pE). Non-cross reacts by W.B. with Human Amyloidβ (1-40), (1-42) and (1-43).
Package Form	Lyophilized product from 1.0mL PBS containing 1 % BSA and 0.05 % NaN3
Storage Condition	2 - 8 ℃
Poisonous and Deleterious Substances	Applicable
Cartagena	Not Applicable
Package Size 1	50 μg
Package Size 2	5 μg
Remarks1	The commercial use of products without our permission is prohibited. Please make sure to contact us and obtain permission.

Product Description

The first case of Alzheimer's disease (AD) was reported by Dr. A. Alzheimer, the
German neuropathologist in 1907. The plaques which appear in the brains of AD
patients mostly consist of Amyloidβ protein and it has been considered as the
major cause of AD. Amyloidβ is a peptide which consists of 40 to 43 amino acids
peptide and it is produced by cleaving by β- and γ- secretase from the amyloid
precursor protein (APP) which is a trans-membrane protein consists of 695, 751,
or 770 amino acids. Human Amyloidβ (N3pE-42) in senile plaques was
discovered by Saido et al. in 1995 as a new Amyloidβ molecule which is
Amyloidβ 42 modified glutamate at the 3rd position of N-terminal to
pyroglutamate and it has been focused its functions in research.